Wynn With This Just In

Clinical Articles Brought to You by Lexicomp
and Dr. Richard L. Wynn

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The purpose of this column is to keep professionals informed of recent reports regarding drugs and other events which may influence dental treatment. These reports will be gleaned from scientific journals, screened for dissemination, and presented on a timely basis and with great accuracy.

It is hoped the dental professional will reap significant benefit from this information, and it will contribute to superior patient care.

Each month a new article will be published. If you are not on our mailing list but would like to receive these newsletters, sign up now!

CURRENT

Updating the Management of the Dental Patient at Risk for Osteonecrosis of the Jaw Bone (ONJ) While Taking Bisphosphonates or Denosumab (Prolia®) - Latest Reports from the American Dental Association
December 2011

PREVIOUS

Ketorolac Nasal Spray (Sprix®) — The Data Looks Good as a Very Effective Non-Narcotic Acute Pain Reliever after Surgery
November 2011

Over-the-Counter Ibuprofen and Acetaminophen in Combination are Superior to Each Agent Alone in Treating Postoperative Pain
October 2011

2,408 Patient Cases of Bisphosphonate-Associated Osteonecrosis of the Jaw Bone: The Most Extensive Review to Date
September 2011

Rivaroxaban (Xarelto®) & Ticagrelor (Brilinta®): More Blood Thinners Added to the Growing Family
August 2011

Bevacizumab (Avastin®): Another Drug Associated With Osteonecrosis of the Jaw
July 2011

Denosumab and Its Association With Osteonecrosis of the Jaw: More Reports
June 2011

Use of Lexi-Interact to Evaluate Drug Interactions and Bleeding in Patients taking Multiple Medications, including Warfarin, and Undergoing Dental Surgery
May 2011

Once-Yearly 5 Milligram Zoledronic Acid Intravenous Infusion (Reclast®) for Osteoporosis is Most Likely Not Associated With Osteonecrosis of the Jaw.
April 2011

A New Study Shows that Ibuprofen (Motrin?) 800 mg Three Times Daily Diminishes the Antiplatelet Effects of Daily Baby Aspirin
March 2011

FDA Limits Acetaminophen in Prescription Combination Pain Relievers to 325 mg. Also, Dabigatran (Pradaxa®), a New Anticoagulant You Will See in Cardiovascular Patients.
February 2011

Actiq®, The Sugar-Loaded Opiate Lollipop and the Risk for Tooth Decay
December 2010

The Latest on the Occurrence of Paresthesia Associated with Local Anesthetics - Reports from 2009 and 2010
November 2010

Botulinum Toxin, aka Botox®, Dysport®, Myobloc®: Pharmacology 101
October 2010

Is There an Aspirin Resistance? Not if You Remember to Take Your Daily Aspirin!
September 2010

A New Class of Drugs Called Anti-RANKL Agents May Be Associated With Osteonecrosis of the Jaw
August 2010

Twice-a-day Toothbrushing Associated With Decreased Levels of C-reactive Protein and Decrease Risk of Heart Disease.
July 2010

Two reports on antidepressants: They are the top drug group for drug-related hospital admissions; they have questionable efficacy against mild to moderate forms of mental depression.
June 2010

Low occurrence of osteonecrosis of the jaw in cancer patients exposed to bisphosphonates and undergoing surgical tooth extractions. Also, few implant failures reported in another study of patients with a history of bisphosphonate therapy.
May 2010

Recent data on the value of the CTX test as predictive of osteonecrosis of the jaw bone in patients exposed to bisphosphonates.
April 2010

Mayo Clinic study shows that dental procedures are not a risk factor in prosthetic hip or knee infections. Authors call for reconsideration of administering antibiotics to all patients with prosthetic hip or knee joints who undergo dental treatment.
March 2010

A New Report: Prevalence of Osteonecrosis of the Jaw in Patients Using Fosamax®-type Drugs is 0.1%
February 2010

Update on Aspirin Alerts
December 2009

Statin Users Taking CoQ10 Supplements
November 2009

Relationship Between C-reactive Protein & Periodontal Disease - Connecting Some of the Dots
October 2009

Prasugrel (Effient™), A Platelet Aggregation Inhibitor that is the New Kid on the Block Also: FDA Finalizes Device Ruling for Mercury and Dental Amalgam
September 2009

Update on Oral Bisphosphonate-Associated Osteonecrosis of the Jaw: New Informational Statement by the ADA; Oral Surgery Literature Reiterates Prevalence is Low
August 2009

Introducing a new drug monograph field, "Effects on Bleeding". Also, antidepressants are associated with increased bleeding.
July 2009

Premedication in Dental Patients with Joint Replacements
June 2009

Important Updates from the AAOS and ADA
May 2009

Aspirin and Heart Attacks
April 2009

Clopidogrel (Plavix®) as an Antiplatelet Agent - Genetics May Affect Drug Responsiveness
March 2009

The Safety of OraVerse™ - a Dental Drug that Speeds Up Return to Normal After Soft-tissue Anesthesia
February 2009

OraVerse™ - A Newly Approved Drug that is Effective in Children in Reversing Soft-tissue Local Anesthesia
January 2009

OraVerse™ - A Newly Approved Drug That Speeds Up Return to Normal After Soft-tissue Anesthesia
November 2008

Prevalence rate of necrotic jaw bone in patients taking Fosamax®-type drugs continues to be low. Plus, more on dental implant success in Fosamax patients.
October 2008

Endocarditis-Causing Bacteria Show Up in the Bloodstream After Toothbrushing
September 2008

Dental Amalgam, the FDA, and Two Safety Studies in Children
August 2008

Vitamin D - New Reports Boost Its Potential as an Anti-Inflammatory
July 2008

Alpha-Lipoic Acid Useful in Treating Burning Mouth Syndrome
June 2008

High Blood Pressure and Underactive Thyroid Gland (Hypothyroidism)
May 2008

Varenicline (Chantix™) is effective in helping smokers quit, but it is not without problems.
April 2008

Bisphosphonates and Dental Implants
March 2008

A Review of the Harvard Fosamax® Study
February 2008

Fosamax® and Osteonecrosis of the Jaw – Some New and Frequently Asked Questions
December 2007

The Experts Weigh In On Osteonecrosis of the Jaw and Bisphosphonates: A New Task Force Report
November 2007

New American Heart Association Guidelines for Preventing Heart Disease in Women
October 2007

Where are we with the benefits of aspirin in women?
September 2007

Information to the Patient from the ADA on the Issues of: (1) The change in guidelines for antibiotic prophylaxis; (2) Oral bisphosphonates and osteonecrosis of the jawbone; (3) The stent patient on aspirin and Plavix®
August 2007

Additional Treatment Options in the Management of Osteoporosis
July 2007

Osteonecrosis of the Jaw in Cancer After Treatment with Bisphosphonates: More Information from Australia
June 2007

New Guidelines for the Prevention of Infective Endocarditis - the Bottom Line
May 2007

More on the Frequency of Oral Bisphosphonate-Associated Osteonecrosis of the Jaw: A New Report from Australia
April 2007

Nonsteroidal Anti-Inflammatory Drug Use in the First Trimester of Pregnancy Increases the Risk of Congenital Anomalies
March 2007

Strong Advisory Warning Against the Discontinuation of Dual Aspirin/Clopidogrel (Plavix®) Antiplatelet Therapy in Patients with Coronary Artery Stents
Feb. 2007

Articaine (Septocaine®) Formulation with Less Vasoconstrictor Gains FDA Approval
Jan. 2007

Ibuprofen Dosing and Naproxen Use in Patients on Cardioprotective Aspirin
Nov 2006

Ibuprofen Blunts Aspirin's Cardioprotection. FDA Issues Warning
Oct 2006

Johns Hopkins and the Mayo Clinic Speak to the Issue of Bisphosphonate-Associated Osteonecrotic Jaw Bone (ONJ)
Sep 2006

More Findings on the Association Between Bisphosphonates and Osteonecrosis of the Jaw
Aug 2006

Fosamax, Boniva and Other Oral Bisphosphonates and Necrotic Jaw Bone
July 2006

Bisphosphonate-associated osteonecrotic jawbone - continuing with more reports relative to dental patient management
June 2006

Bisphosphonates, including alendronate (Fosamax®), and ONJ
May 2006